A
compound found in green tea and apples can help reduce the risk of heart
attacks and cancer, says a new research. Polyphenols in green tea and apples
block a key molecule which in the body can trigger atherosclerosis and is a
target for some anti-cancer drugs, the findings showed.
Atherosclerosis
can lead to heart attack, stroke, or even death. “These data provide a
plausible mechanism, which links bioactive compounds in food with their
beneficial effects,” said research leader Paul Kroon at the Institute of Food
Research (IFR) in Britain.
In
the body, the molecule ascular endothelial growth factor (VEGF) is a main
driver of blood vessel formation in diseased cells via a process called
angiogenesis. Angiogenesis is crucial in cancer progression as well as in the
development of atherosclerotic plaques and plaque rupture which can cause heart
attacks and stroke.
Using
cells derived from human blood vessels, the researchers found that the
polyphenols—epigallocatechin gallate (EGCG) from green tea and procyanidin from
apples—stopped a crucial signalling function of VEGF. “If this effect happens
in the body as well, it provides very strong evidence for a mechanism that
links dietary polyphenols and beneficial health effects,” Kroon noted.
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